Roma hand Fabio Borini the third prong of their trident with Francesco Totti and Erik Lamela, but Simon Kjaer is benched against Bologna.
The Giallorossi have won three Serie A games on the trot, but their confidence was hit by a midweek 3-0 Coppa Italia quarter-final defeat to Juventus.
Luis Enrique tinkers with his formation again, giving Borini the nod ahead of Bojan Krkic, while Leandro Greco and Juan go into the starting XI rather than Fabio Simplicio and Kjaer.
Daniele De Rossi, Pablo Daniel Osvaldo and Nicolas Burdisso are out of action.
Bologna have won at the Olimpico just once in the last 32 years and are missing the suspended Gaston Ramirez.
Also absent are Nico Pulzetti, Panagiotis Kone and ex-Roma defender Simone Loria.
Coach Stefano Pioli hands a surprise starting spot to intriguing 19-year-old Saphir Taider, who as of this week is co-owned by Juventus.
Roma: Stekelenburg; Rosi, Juan, Heinze, Taddei; Pjanic, Gago, Greco; Lamela, Totti, Borini
Roma bench: Curci, Kjaer, Jose Angel, Viviani, Perrotta, Simplicio, Bojan
Bologna: Gillet; Antonsson, Portanova, Raggi; Garics, Perez, Mudingayi, Morleo; Diamanti, Taider; Di Vaio
Bologna bench: Agliardi, Cherubin, Rubin, Rennella, Crespo, Gimenez
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.