Inter have Wesley Sneijder, Diego Forlan and Giampaolo Pazzini in a 4-2-3-1 system against Bologna this evening.
The Nerazzurri desperately need a positive result after picking up one point from their last five games, including a 1-0 home defeat to bottom of the table Novara.
Diego Milito, Dejan Stankovic, Ricky Alvarez, Walter Samuel and new signing Fredy Guarin are on the treatment table.
Sneijder starts in a 4-2-3-1 system that was already experimented against Novara, joined by Forlan and Under-21 international Marco Davide Faraoni behind lone striker Pazzini.
Bologna must do without Simone Loria, but have Alessandro Diamanti and Gaston Ramirez as support for Marco Di Vaio.
Kick-off at San Siro is at 19.45 UK time, a Serie A fixture brought forward so Inter can better prepare for the Champions League match with Olympique Marseille on Wednesday.
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 23 Ranocchia, 55 Nagatomo; 4 Zanetti, 19 Cambiasso; 37 Faraoni, 10 Sneijder, 9 Forlan; 7 Pazzini
Inter bench:12 Castellazzi, 26 Chivu, 18 Poli, 17 Palombo, 20 Obi, 28 Zarate, 20 Castaignos
Bologna: 1 Gillet; 84 Raggi, 90 Portanova, 5 Antonsson; 8 Garics, 15 Perez, 26 Mudingayi, 3 Morleo; 10 Ramirez, 23 Diamanti; 9 Di Vaio
Bologna bench:25 Agliardi, 6 Taider, 13 Pulzetti, 21 Cherubin, 33 Kone, 48 Rubin, 99 Acquafresca