Lazio are forced to use Cristian Ledesma in defence and give Emiliano Alfaro his debut in a trip to Fabrizio Miccoli’s Palermo.
The Aquile are without a host of key players, including Stefan Radu, Marius Stankevicius, Tommaso Rocchi, Giuseppe Biava, Cristian Brocchi, Lorik Cana and the suspended Mobido Diakite and Abdoullay Konko.
This means huge changes, as Cristian Ledesma becomes a makeshift centre-back and January signing Alfaro receives his Serie A debut.
Palermo must do without Abel Hernandez, Armin Bacinovic and Edgar Alvarez for this match, but Miccoli returns to the starting XI.
He is partnered by Igor Budan and Josip Ilicic.
Palermo: 1 Viviano, 31 Pisano, 3 Silvestre, 2 Mantovani, 42 Balzaretti; 8 Migliaccio, 23 Donati, 5 Barreto; 27 Ilicic; 19 Budan, 10 Miccoli
Palermo bench: 33 Tzorvas, 6 Munoz, 20 Acquah, 7 Della Rocca, 14 Bertolo, 17 Vazquez, 16 Zahavi
Lazio: 22 Marchetti, 78 Zauri, 24 Ledesma, 3 Dias; 15 Gonzalez, 8 Hernanes, 11 Matuzalem, 87 Candreva, 19 Lulic; 25 Klose, 30 Alfaro
Lazio bench: 1 Bizzarri, 5 Scaloni, 41 Zampa, 13 Sbraga, 14 Garrido, 6 Mauri, 18 Kozak
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!