Claudio Ranieri takes a bold stand against Catania and drops Wesley Sneijder to the bench, as he fights for his Inter job.
The Nerazzurri are increasingly desperate with seven defeats from their last eight official games, so absolutely must win at 19.45 UK time.
Luc Castaignos continues his three-match ban for spitting at an opponent, while Fredy Guarin, Ricky Alvarez, Andrea Ranocchia and Cristian Chivu are injured.
Ranieri has taken a bold step in dropping Sneijder, whose tactical issues have been partly blamed for the recent crisis.
This means he can play a classic 4-4-2 system without the need to squeeze in a trequartista, but still pulls a surprise by fielding Diego Forlan out wide.
Catania are on fine form, but come to San Siro without Marco Biagianti, Andrea Campagnolo and Alessandro Potenza.
Alejandro Gomez, Gonzalo Bergessio and Pablo Barrientos complete the trident, as the Sicilians have no intention of coming to San Siro in order to defend.
Marco Motta returns to the line-up after his suspension.
Inter: 1 Julio Cesar; 55 Nagatomo, 6 Lucio, 25 Samuel, 4 Zanetti; 37 Faraoni, 17 Palombo, 19 Cambiasso, 9 Forlan; 22 Milito, 7 Pazzini
Inter bench:12 Castellazzi, 2 Cordoba, 10 Sneijder, 18 Poli, 20 Obi, 28 Zarate, 40 Juan Jesus
Catania: 20 Carrizo; 11 Motta, 6 Legrottaglie, 3 Spolli, 12 Marchese; 13 Izco, 10 Lodi, 4 Almiron; 17 Gomez, 18 Bergessio, 28 Barrientos
Catania bench:1 Kosiscki, 8 Seymour, 14 Bellusci, 16 Llama, 19 Ricchiuti, 22 Ebagua, 33 Capuano
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!