Inter return to the 4-4-2 system with Diego Milito and Giampaolo Pazzini, but Atalanta must rely on Under-21 international Guido Marilungo.
The Nerazzurri may have ended their run of six weeks without a victory, but were knocked out of the Champions League by Olympique Marseille on Tuesday.
Wesley Sneijder, Ricky Alvarez, Dejan Stankovic, Cristian Chivu and Fredy Guarin are all unavailable, so there are few midfield options.
Claudio Ranieri returns to the 4-4-2 system and Esteban Cambiasso is back in the starting XI after he was dropped against Chievo and OM.
Atalanta also have to make changes, as top scorer German Denis is out with a calf injury, joining Matteo Brighi, Stefano Lucchini, Federico Peluso and Daniele Capelli.
Under-21 international Marilungo is therefore supported by Alessandro Carrozza.
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 25 Samuel, 55 Nagatomo; 4 Zanetti, 18 Poli, 19 Cambiasso, 20 Obi; 22 Milito, 7 Pazzini
Inter bench:12 Castellazzi, 23 Ranocchia, 37 Faraoni, 17 Palombo, 9 Forlan, 28 Zarate, 30 Castaignos
Atalanta: 47 Consigli; 77 Raimondi, 32 Ferri, 5 Manfredini, 6 Bellini; 7 Schelotto, 21 Cigarini, 17 Carmona, 11 Moralez; 18 Carrozza; 89 Marilungo
Atalanta bench:78 Frezzolini, 2 Stendardo, 10 Bonaventura, 28 Gabbiadini, 44 Cazzola, 79 Ferreira Pinto, 90 Tiribocchi
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!