Milan have Zlatan Ibrahimovic and Stephan El Shaarawy against Roma’s trident Francesco Totti, Fabio Borini and Pablo Daniel Osvaldo.
The Serie A leaders welcome Luis Enrique’s team at 17.00 UK time just days before the Champions League quarter-final with Barcelona.
As always, Massimiliano Allegri has an injury crisis to contend with that has ruled out Maxi Lopez, Alexandre Pato, Pippo Inzaghi, Robinho, Ignazio Abate, Mathieu Flamini, Antonio Cassano and Rodney Strasser.
Luca Antonini is also suspended, while Alessandro Nesta and Kevin-Prince Boateng are only fit for the bench.
The defence is revamped with Daniele Bonera taking right-back and Djamel Mesbah on the left. Urby Emanuelson is again trequartista behind only available strikers Ibra and El Shaarawy.
Roma welcome back Totti, but must do without Juan, Nicolas Burdisso, Marco Cassetti, Leandro Greco and substitute goalkeeper Bogdan Lobont.
The captain is joined in attack by Borini and Osvaldo, while Marquinho gets the midfield nod.
Rodrigo Taddei and Aleandro Rosi represent very attacking full-backs for the visitors.
Milan: Abbiati; Bonera, Mexes, Thiago Silva, Mesbah; Nocerino, Ambrosini, Muntari; Emanuelson; Ibrahimovic, El Shaarawy
Roma: Stekelenburg; Rosi, Kjaer, Heinze, Taddei; Gago, De Rossi, Marquinho; Borini, Totti, Osvaldo