Udinese have Diego Fabbrini and Pablo Armero supporting Antonio Di Natale as they take on Mattia Destro’s Siena.
The Friulani still have a chance of climbing into third place after Lazio’s defeat to Parma last night, while rivals Napoli face unbeaten Juventus this evening.
Antonio Floro Flores and Joel Ekstrand sit out bans, joining the injured Mehdi Benatia, Damiano Ferronetti, Emmanuel Badu, Mauricio Isla, Dusan Basta and Cristian Battocchio.
Under-21 international Fabbrini is picked ahead of Gabriel Torje to support Di Natale.
Siena are not yet mathematically safe from relegation and want to make sure of their Serie A status.
Top scorer Emanuele Calaiò is out for the rest of the season with a fractured shin, joining Francesco Bolzoni and Angelo on the treatment table.
Destro takes the lead in attack with Jorge Larrondo, moving Franco Brienza into midfield.
Siena: Pegolo, Terzi, Rossettini, Contini, Giorgi, Vergassola, Gazzi, Brienza, Del Grosso, Destro, Larrondo
Siena bench:Brkic, Vitiello, Rossi, Parravicini, Mannini, D’Agostino, Bogdani
Udinese: Handanovic, Coda, Danilo, Domizzi, Pereyra, Pinzi, Pazienza, Asamoah, Armero, Fabbrini, Di Natale
Udinese bench:Padelli, Neuton, Fernandes, Barreto, Abdi, Torje, Pasquale