Inter confirm their 4-3-3 system under Andrea Stramaccioni with Mauro Zarate, Diego Milito and Diego Forlan against Cagliari’s Mauricio Pinilla.
There is a very South American flavour to the match at the Stadio Nereo Rocco in Trieste, played here because of reconstruction work at the Sant’Elia in Sardinia.
The Nerazzurri won on their debut under new Coach Stramaccioni, albeit squeezing past Genoa in a crazy 5-4 thriller, but here have to do without Douglas Maicon, Wesley Sneijder, Ricky Alvarez and Luc Castaignos.
Lucio and Julio Cesar are also suspended, so Luca Castellazzi and Andrea Ranocchia get rare starts. The 4-3-3 system is confirmed with a South American trident, while Fredy Guarin gets his first start in an Inter jersey.
Cagliari miss Daniele Dessena, Rui Sampaio and Sebastian Eriksson, while goalkeeper Michael Agazzi is able to play despite not being 100 per cent fit.
Andrea Cossu acts as trequartista behind front two Thiago Ribeiro and Pinilla.
Cagliari: 1 Agazzi; 14 Pisano, 13 Astori, 21 Canini, 31 Agostini; 20 Ekdal, 5 Conti, 4 Nainggolan; 7 Cossu; 19 Thiago Ribeiro, 51 Pinilla
Cagliari bench: 25 Avramov, 15 Bovi, 24 Perico, 3 Ariaudo, 18 Nenè, 9 Larrivey, 23 Ibarbo
Inter: 12 Castellazzi; 4 Zanetti, 23 Ranocchia, 25 Samuel, 26 Chivu; 14 Guarin, 5 Stankovic, 19 Cambiasso; 28 Zarate, 22 Milito, 9 Forlan
Inter bench: 21 Orlandoni, 2 Cordoba, 55 Nagatomo, 17 Palombo, 18 Poli, 20 Obi, 7 Pazzini
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!