This is to all intents and purposes a play-off for the third Champions League berth, as Napoli have to revamp their tactics to take on stuttering Lazio.
The fight for third place rages on and these sides need a win, especially after Udinese’s victory over Parma today put them level with Lazio.
The Biancocelesti seem to be in a permanent injury crisis and for this game they are without Miroslav Klose, Marius Stankevicius, Senad Lulic, Francelino Matuzalem and Andre Dias.
Tommaso Rocchi is the centre-forward with Antonio Candreva and Lorik Cana getting rare starts.
Napoli have so many absentees that Walter Mazzarri has to abandon his three-man defence in favour of a 4-3-2-1 system.
Camilo Zuniga and Walter Gargano are suspended, joining the injured Christian Maggio, Marco Donadel and Antonio Rosati.
Andrea Dossena is in the squad, but not fit to start, while Goran Pandev steps in against his old club to move Marek Hamsik into a deeper role.
Kick-off is 20.00 UK time at the Stadio Olimpico in Rome.
Lazio: Marchetti; Konko, Diakitè, Biava, Radu; Cana, Ledesma; Candreva, Hernanes, Mauri; Rocchi
Lazio bench: Bizzarri, Scaloni, Garrido, Gonzalez, Brocchi, Kozak, Alfaro. All. Reja
Napoli: De Sanctis; Campagnaro, Cannavaro, Britos, Aronica; Dzemaili, Inler, Hamsik; Pandev, Lavezzi; Cavani
Napoli bench: Colombo, Fideleff, Grava, Fernandez, Dossena, Dezi, Vargas