Juventus have picked Fabio Quagliarella and Mirko Vucinic to face off against Lazio, who dropped Hernanes to the bench.
The Bianconeri leapfrogged Milan to the top of the table on Easter Saturday, but as Milan won at Chievo last night, they need a victory to retain the leadership.
They welcome third-placed Lazio who are fresh from beating Napoli to consolidate that third Champions League berth.
Antonio Conte has a full squad to choose from and has picked Vucinic and Quagliarella to lead the 3-5-2 system.
Simone Pepe and Paolo De Ceglie are pushed wide to protect a three-man defence, meaning Stephan Lichtsteiner is on the bench against his former club.
Lazio have to deal with an injury crisis that has ruled out Miroslav Klose, Andre Dias, Marius Stankevicius, Senad Lulic, Abdoullay Konko and Stefan Radu.
Veteran Tommaso Rocchi therefore starts in attack with support from Stefano Mauri, Alvaro Gonzalez and ex-Juve man Antonio Candreva.
It means Hernanes is dropped to the bench after a period of poor form, joining the not 100 per cent fit Francelino Matuzalem.
Juventus:Buffon; Barzagli, Bonucci, Chiellini; Pepe, Vidal, Pirlo, Marchisio, De Ceglie; Quagliarella, Vucinic
Juventus bench:Storari, Caceres, Lichtsteiner, Giaccherini, Borriello, Matri, Del Piero
Lazio: Marchetti; Scaloni, Diakitè, Biava, Garrido; Cana, Ledesma; Gonzalez, Mauri, Candreva; Rocchi
Lazio bench: Bizzarri, Zauri, Matuzalem, Brocchi, Hernanes, Alfaro, Kozak
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!