Wesley Sneijder is on the bench as Inter adopt a spectacular 4-2-4 formation against a completely reshuffled Fiorentina side in the lunchtime kick-off.
The Sunday action begins at 11.30 UK time in the Stadio Artemio Franchi, when two of the biggest disappointments of the campaign face off.
The Nerazzurri are still potentially in the race for a Champions League spot, but have left themselves a mountain to climb.
Coach Andrea Stramaccioni is unbeaten since taking over and for the first time has Sneijder at his disposal, although the Dutchman is only on the bench.
Douglas Maicon also returns from injury, but Luc Castaignos and the suspended Walter Samuel are absent.
Instead, Stramaccioni adopts a spectacular 4-2-4 system with Diego Forlan, Ricky Alvarez, Mauro Zarate and Diego Milito.
Fiorentina find themselves struggling to avoid relegation in a dismal campaign and Delio Rossi is forced to completely revamp his line-up.
Amauri is suspended, joining the injured Stevan Jovetic, Juan Manuel Vargas and Per Kroldrup.
It means Alessio Cerci and Adem Ljajic are the only available strikers, neither of them first choices nor centre-forwards.
Riccardo Montolivo is passed fit to start despite not being 100 per cent. The Viola are currently only three points clear of Lecce and the drop zone.
Fiorentina: 1 Boruc; 31 Camporese, 14 Natali, 15 Nastasic; 16 Cassani, 13 Kharja, 85 Behrami, 21 Lazzari, 23 Pasqual; 7 Cerci; 22 Ljajic
Fiorentina bench: 89 Neto, 5 Gamberini, 10 Olivera, 17 Salifu, 18 Montolivo, 29 De Silvestri, 37 Acosty
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 26 Chivu, 4 Zanetti; 18 Poli, 19 Cambiasso; 9 Forlan, 11 Alvarez, 28 Zarate; 22 Milito
Inter bench: 12 Castellazzi, 23 Ranocchia, 55 Nagatomo, 5 Stankovic, 10 Sneijder, 14 Guarin, 7 Pazzini