Milan have Zlatan Ibrahimovic, Robinho and Clarence Seedorf against Marco Di Vaio’s Bologna.
The Rossoneri hope today’s games can be a turning point in the season, as they are one point behind leaders Juventus ahead of tonight’s clash with Roma.
As always, Massimiliano Allegri is dealing with an injury crisis that rules out Thiago Silva, Kevin-Prince Boateng, Alexandre Pato, Massimo Ambrosini, Pippo Inzaghi and Flavio Roma.
Ibrahimovic is supported by Robinho and Seedorf, while Daniele Bonera replaces Philippe Mexes in defence.
Bologna conquered San Siro earlier this season when beating Inter 3-0 and have also taken points off Juve, so are not to be underestimated.
Veteran hitman Di Vaio leads the way with Alessandro Diamanti and Gaston Ramirez.
Nico Pulzetti, Jose Crespo, Casarini, Rene Krhin and goalkeeper Jean-Francois Gillet are sidelined.
It means Federico Agliardi receives a rare start between the posts.
Milan: Abbiati; Abate, Nesta, Bonera, Antonini; Nocerino, van Bommel, Muntari; Seedorf; Ibrahimovic, Robinho
Bologna: Agliardi; Raggi, Portanova, Cherubin, Garics; Perez, Mudingayi, Morleo; Ramirez, Diamanti; Di Vaio