Lazio rely on Tommaso Rocchi and Hernanes in a very dangerous encounter with on form Lecce.
The Biancocelesti are clinging on to the Champions League spot despite some recent poor results and an injury crisis.
Miroslav Klose, Abdoullay Konko, Senad Lulic, Cristian Brocchi and Marius Stankevicius are sidelined along with the suspended Stefano Mauri and Libor Kozak.
It means Rocchi takes the helm with support from Hernanes and Antonio Candreva.
Lecce are in great shape and have caused quite a few upsets recently, while they were beaten 3-2 when these sides met earlier this season.
Manuele Blasi sits out a ban with the injured Leonardo Miglionico and Julio Sergio, but Udinese-owned Luis Muriel and Juan Cuadrado are the ones to watch.
Massimo Oddo is the experienced head in defence against his former club.
Lazio: Marchetti; Scaloni, Diakitè, Biava, Garrido; Ledesma, Matuzalem; Gonzalez, Hernanes, Candreva; Rocchi
Lazio bench: Bizzarri, Dias, Zauri, Cana, Zampa, Alfaro, Rozzi
Lecce: Benassi; Oddo, Esposito, Tomovic; Cuadrado, Delvecchio, Giacomazzi, Bertolacci, Brivio; Muriel, Di Michele
Lecce bench: Petrachi, Di Matteo, Carrozzieri, Giandonato, Obodo, Bojinov, Corvia