Goran Pandev partners Edinson Cavani as Napoli welcome Palermo in their bid to hold on to third place.
Walter Mazzarri’s men are one of four teams currently tied in the last Champions League qualifying spot and take to the field at 19.45 UK time.
Hugo Campagnaro and Marco Donadel are still injured, joined by the suspended Blerim Dzemaili.
Ezequiel ‘Pocho’ Lavezzi is still not fit enough to start, but Pandev starts in support of Cavani.
Palermo are comfortably mid-table, but need a boost after their Sicilian derby stalemate.
Bortolo Mutti is forced into a few changes, as Fabrizio Miccoli, Andrea Mantovani, Federico Balzretti and Francesco Della Rocca are all on the treatment table.
The Rosanero have not win here since a 1979 Coppa Italia tie, earning four draws and as many defeats in all competition.
Their most recent Serie A victory at the San Paolo was way back in December 1951.
Napoli: 1 De Sanctis, 21 Fernandez, 28 Cannavaro, 6 Aronica; 11 Maggio, 23 Gargano, 88 Inler, 17 Hamsik, 18 Zuniga; 29 Pandev, 7 Cavani
Napoli bench: 15 Colombo, 2 Grava, 3 Fideleff, 85 Britos, 8 Dossena, 22 Lavezzi, 16 Vargas.
Palermo: 1 Viviano; 6 Munoz, 15 Milanovic, 18 Labrin; 31 Pisano, 8 Migliaccio, 23 Donati, 5 Barreto, 14 Bertolo; 27 Ilicic, 11 Hernandez
Palermo bench: 33 Tzorvas, 13 Aguirregaray, 21 Bacinovic, 17 Vazquez, 16 Zahavi, 19 Budan, 24 Mehmeti