New Juventus buy Luca Toni starts alongside Amauri, dropping Alex Del Piero, while Napoli rely on their young trident.
Since Fabio Quagliarella's devastating knee injury ruled him out for six months, the Bianconeri brought in Toni from Genoa on Friday.
He is thrown straight into the starting XI, but his partner is surprisingly Amauri rather than captain Del Piero.
There are changes elsewhere too with Zdenek Grygera and Armand Traore stepping in for Fredrik Sorensen and Fabio Grosso.
Fabio Melo begins his three-match ban for kicking Parma's Massimo Paci in the face, while Leandro Rinaudo, Jorge Martinez, Paolo De Ceglie, Vincenzo Iaquinta and the aforementioned Quagliarella are injured.
Napoli boss Walter Mazzarri has no concerns and an entire squad to choose from, picking his favoured trident attack.
Ezequiel Lavezzi, Marek Hamsik and Edinson Cavani lead the way, while the only change is Gianluca Grava in for Salvatore Aronica.
Both sides lost heavily on Thursday and are eager to prove a point as well as battle for the top spots, especially as Napoli would go into second with a victory.
Napoli: De Sanctis; Grava, Cannavaro, Campagnaro; Maggio, Gargano, Pazienza, Dossena; Hamsik; Lavezzi, Cavani
Juventus: Storari; Grygera, Bonucci, Chiellini, Traore'; Krasic, Marchisio, Aquilani, Pepe; Toni, Amauri
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!