Clarence Seedorf, Andrea Pirlo and Rodney Strasser are out of the match with Cesena, leaving Milan with midfield problems.
Seedorf has not been included in the squad for the Sunday evening encounter, apparently due to a knee issue.
Pirlo made his first appearance of 2011 in the Coppa Italia midweek against Bari, but lasted just 20 minutes before limping off with a thigh problem.
One of his natural replacements, youth team player Strasser, is also out of action along with Gianluca Zambrotta, Kevin-Prince Boateng, Marco Amelia, Marek Jankulovski and Pippo Inzaghi.
Milan squad: Abbiati, Roma, Abate, Antonini, Bonera, Nesta, Oddo, Papastathopoulos, Thiago Silva, Yepes, Ambrosini, Flamini, Gattuso, Merkel, Cassano, Ibrahimovic, Pato, Robinho