Inter hope to end their San Siro curse tonight with Antonio Cassano and Diego Milito, but they welcome a Fiorentina in stunning form.
The Nerazzurri are still looking for their first home victory of the season in all competition.
Wesley Sneijder, Rodrigo Palacio, Cristian Chivu, Dejan Stankovic and MacDonald Mariga are all out of action.
It means that Cassano starts in attack with Milito and support from Philippe Coutinho in what looks to be another 3-5-2 system.
Fiorentina have played some of the best football in Serie A this term and are in great shape under Coach Vincenzo Montella.
Alberto Aquilani, Mounir El Hamdaoui and Francesco Della Rocca are still on the treatment table.
Stevan Jovetic is partnered by Adem Ljajic with Borja Valero and David Pizarro in midfield.
Inter: Handanovic; Ranocchia, Samuel, Juan Jesus; Nagatomo, Zanetti, Cambiasso, Gargano, Coutinho; Milito, Cassano
Inter bench: Castellazzi, Belec, Silvestre, Alvarez, Guarin, Mudingay, Obi, Pereira, Duncan, Jonathan, Livaja
Fiorentina: Viviano; Roncaglia, Rodriguez, Tomovic; Cuadrado, Romulo, Pizarro, Borja Valero, Pasqual; Ljajic, Jovetic
Fiorentina bench: Neto, Hegazi, Olivera, Lupatelli, Fernendez, Savic, Cassani, Seferovic, Llama, Migliaccio, Toni