Philippe Coutinho and Antonio Cassano lead the way as Inter welcome Partizan Belgrade in the Europa League at 18.00 BST.
The Nerazzurri have an excellent record against this club, winning three and drawing one, though those fixtures were back in 1963-64 and 1990-91.
However, Andrea Stramaccioni needs to end his San Siro curse in Europe after failing to win any of their three home games this season.
Esteban Cambiasso is again used at the centre of a three-man defence, resting Andrea Ranocchia, Walter Samuel, Diego Milito and Javier Zanetti.
Coutinho acts as support to strikers Marko Livaja and Cassano.
Partizan Belgrade rely on starlet Lazar Markovic and captain Sasha Ilic, but leave Aleksandar Lazevski, Sasa Markovic and the Scepovic brothers on the bench.
The Serbians are bottom of Group H with one point from two games and are yet to score a single goal.
Inter: Handanovic; Silvestre, Cambiasso, Juan; Jonathan, Mudingayi, Guarin, Alvaro Pereira; Coutinho; Cassano, Livaja
Inter bench: Belec, Zanetti, Ranocchia, Samuel, Gargano, Palacio, Milito
Partizan Belgrade: Petrovic; Miljkovic, Ivanov, Ostojic, Volkov; Smiljanic, Medo; L Markovic, S Ilic, Tomic; Mitrovic
Partizan bench: R Ilic, Sretenovic, Lazevski, S Markovic, Jojic, S Scepovic, M Scepovic