Massimiliano Allegri desperately clings to the Milan bench and sticks with his 3-4-3 system as Genoa debut under new Coach Gigi Del Neri.
These two clubs have had disastrous starts to the campaign and one already wielded the axe, while the other is being sharpened.
Allegri unveiled his new 3-4-3 tactic in the 1-0 Champions League defeat to Malaga and stands by the experiment tonight.
Kevin-Prince Boateng had been expected to start, but a minor knee problem has again ruled him out.
Instead, Alexandre Pato gets his first start in eight months after a series of thigh strains, but Mattia De Sciglio has flu to join the injured Robinho, Djamel Mesbah, Sulley Muntari, Didac Vila and Rodney Strasser.
Christian Abbiati is only fit for the bench after suffering from a respiratory infection, so Marco Amelia plays against his old teammates.
Genoa cannot field Marco Borriello against his former club, as the striker is sidelined for six weeks with a sprained ankle.
Marco Rossi, Damiano Ferronetti, Juan Manuel Vargas and the suspended Michele Canini are also unavailable on Del Neri’s debut.
Gigi De Canio was sacked last week after Genoa threw away a 2-0 lead to lose 4-2 at home against Roma, the third time they have lost from a winning position this season.
Milan: Amelia; Zapata, Bonera, Yepes; Abate, De Jong, Montolivo, Antonini; Emanuelson, El Shaarawy, Pato
Genoa: Frey; Sampirisi, Bovo, Granqvist, Moretti; Jankovic, Kucka, Tozser, Antonelli; Bertolacci, Immobile
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!