Milan face their crucial match with Malaga using Alexandre Pato, Stephan El Shaarawy, Bojan Krkic and Urby Emanuelson.
Massimiliano Allegri saved his job on Saturday with a 5-1 demolition of Chievo and sticks with the 4-2-3-1 system he used in that game.
Pato steps in for Giampaolo Pazzini, while Nigel De Jong replaces Massimo Ambrosini in midfield.
As Luca Antonini and Djamel Mesbah are still injured, Kevin Constant is again a makeshift full-back.
Malaga are practically qualified for the knockouts already and beat the Rossoneri 1-0 in Spain.
Jeremy Toulalan returns to the squad after missing eight games due to a hamstring strain, but Julio Baptista, Nacho Monreal and Recio are out of action.
Milan: Abbiati; Constant, Mexes, Bonera, Abate; Montolivo, De Jong; El Shaarawy, Bojan, Emanuelson; Pato
Milan bench: Amelia, De Sciglio, Yepes, Boateng, Ambrosini, Robinho, Pazzini
Malaga: Willy; Gamez, Demichelis, Weligton, Sergio Sanchez; Camacho, Iturra; Joaquin, Isco, Eliseu; Saviola
Malaga bench: Kameni, Onyewu, Toulalan, Duda, Portillo, Seba, Santa Cruz