Will Juventus start a new unbeaten run from tonight at Pescara or have Inter broken the spell? Read previews of all this weekend’s games, including the Rome derby and Milan-Fiorentina.
The action from Week 12 begins at 17.00 GMT with Cagliari-Catania, then Juve visit the Stadio Adriatico this evening.
The lunch-time Sunday kick-off is Palermo-Sampdoria between two desperate sides battling relegation.
Fans are spoilt for choice that afternoon with the likes of Milan-Fiorentina, Genoa-Napoli and the thrilling Derby della Capitale.
Inter conclude the weekend in another local derby with Atalanta.