Stevan Jovetic is not even fit for the bench, so Adem Ljajic and Luca Toni take on Atalanta’s Maxi Moralez and German Denis.
Fiorentina are on fine form at the moment and flew into fourth place with a victory over Milan at San Siro last week.
Atalanta also defeated a Milan club, ending Inter’s 10-match winning streak, so they are not to be underestimated.
Jovetic was back in the squad and hoped to take part, but he failed a fitness test this morning and is not even on the bench.
David Pizarro, Alberto Aquilani and Borja Valero remain the midfield trio to watch.
The Orobici aim to do damage down the wings with Ezequiel Schelotto and Giacomo Bonaventura.
Federico Peluso and Facundo Parra sit out bans for the visitors, joining the injured Giampaolo Bellini, Adriano Ferreira Pinto and Daniele Capelli.
Fiorentina: Viviano; Roncaglia, Rodriguez, Savic; Cuadrado, Pizarro, Aquilani, Borja Valero, Pasqual, Ljajic, Toni
Fiorentina bench: Neto, Hegazi, Olivera, El Hamdaoui, Lupatelli, Fernandez, Cassani, Seferovic, Llama, Migliaccio, Tomovic, Romulo
Atalanta: Consigli; Raimondi, Stendardo, Manfredini, Brivio; Schelotto, Cigarini, Carmona, Bonaventura; Moralez, Denis
Atalanta bench: Polito, Frezzolini, Lucchini, Troisi, Scozzarella, Matheu, Ferri, Cazzola, Biondini, Marilungo, De Luca