Miroslav Klose and Abdoullay Konko are out of Lazio’s Europa League match against Tottenham Hotspur.
Klose had been in doubt after picking up a knock in the 0-0 with Juventus on Saturday evening and has not even recovered enough to be on the bench.
Konko is also out of action, but Ederson has been included in midfield.
Lazio squad for Tottenham: Marchetti, Bizzarri, Scarfagna; Biava, Cavanda, Radu, Scaloni, Ciani; Ledesma, Onazi, Mauri, Ederson, Candreva, Lulic, Gonzalez, Hernanes; Floccari, Kozak, Zarate.
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more