Udinese are already out of the Europa League, but hope to do the double over Liverpool after their victory at Anfield.
Kick-off is at the Stadio Friuli at 18.00 GMT.
The Friulani had been top of Group A at one stage, but three consecutive defeats against Young Boys and Anzhi saw them crash out of the competition.
Liverpool are not yet sure of qualification, as Anzhi have already booked their spot in the next round, but the Reds are level with Young Boys, but in front on a head-to-head basis.
In order to qualify, Liverpool must either pick up more points than the Swiss side or beat Udinese.
Antonio Di Natale will enter the history books this evening if he steps on to the field, as he will match Valerio Bertotto’s record of 33 UEFA club competition appearances for Udinese.
He starts from the bench as Francesco Guidolin fields a totally revamped 4-4-1-1 formation with ex-Liverpool goalkeeper Daniele Padelli given a rare outing.
Udinese: Padelli; Faraoni, Heurtaux, Danilo, Pasquale; Pereyra, Badu, Pinzi, Armero; Fabbrini; Ranegie
Udinese bench: Brkic, Benatia, Berra, Frison, Reinthaler, Di Natale, Marsura
Liverpool: Reina; Johnson, Skrtel, Carragher, Enrique; Henderson, Allen, Nuri Sahin; Suso, Suarez, Downing
Liverpool bench: Jones, Coates, Wisdom, J Cole, Sterling, Shelvey, Assaidi
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!