Lazio are already sure of their spot in the next round of the Europa League, but are determined to put first place under lock and key in Maribor.
The Biancocelesti take to the field in Slovenia at 20.05 GMT and a win would mathematically seal top spot regardless of the Tottenham-Panathinaikos score.
Miroslav Klose is injured, so Libor Kozak partners Sergio Floccari in a change to the 3-4-3 system.
Hernanes and Ederson start together, while Lorik Cana takes a new role in central defence.
Lazio won this fixture 1-0 at the Olimpico two months ago, but had also rattled the woodwork several times in that game.
Maribor: Handanovic; Mertelj, Rajcevic, Potokar, Trajkovski; Filipovic, Cvijanovic; Mezga, Tavares, Ibraimi; Beric
Maribor bench: Pridigar, Vidovic, Arghus, Dodlek, Crnic, Komazec, Ploj
Lazio: Bizzarri; Ciani, Cana, Radu; Cavanda, Onazi, Hernanes, Lulic; Ederson, Kozak, Floccari
Lazio bench: Scarfagna, Scaloni, Biava, Gonzalez, Ledesma, Candreva, Rozzi