Juventus are forced to reshuffle due to a series of setbacks as they welcome on-form Udinese and Alex Del Piero is the only fit striker.
The evening kick-off at 19.45 UK time is in Turin and the pressure is piling on Gigi Del Neri, who crashed out of the Coppa Italia this week.
He has few real options when picking his line-up, as the injury crisis has escalated.
Amauri, Vincenzo Iaquinta and Marco Motta also joined the absentee list over the last few days.
Felipe Melo's ban has expired, but he is suffering from flu symptoms, while new buy Andrea Barzagli is on the bench.
Missing are Leandro Rinaudo, Paolo De Ceglie, Fabio Quagliarella, Luca Toni, Armand Traoré and Simone Pepe.
It means the only forward available is Alessandro Del Piero, so winger Jorge Martinez has been pushed up to partner him in the classic 4-4-2 system.
Udinese are on fine form, having recently held Milan to a 4-4 draw and inflicted the only defeat on Leonardo's Inter.
The only absentees are Dusan Basta and Damiano Ferronetti.
It's a special game for Antonio Di Natale, who rejected a transfer to Juventus over the summer.
Juventus: Buffon; Grygera, Bonucci, Chiellini, Grosso; Krasic, Aquilani, Felipe Melo, Marchisio; Martinez, Del Piero
Udinese: Handanovic; Benatia, Zapata, Domizzi; Isla, Pinzi, Inler, Asamoah, Armero; Sanchez, Di Natale