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Second-placed Napoli visit Inter in third for a Scudetto clash, while Juventus welcome back Antonio Conte in their tricky trip to Palermo.
Click here for all the individual match previews from Serie A Week 16 [12], plus reports on Roma-Fiorentina and Atalanta-Parma. [12]
Milan face the threat of snow and an icy reception at Torino, but there are relegation dogfights in Siena, Cagliari and Pescara.
The action continues on Monday evening with Sampdoria-Udinese and Bologna-Lazio.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition [13] - £5,000 monthly.