Miroslav Klose is back as Lazio welcome Inter, who change to a four-man defence with Antonio Cassano and Diego Milito upfront.
This is a battle between two of the surprise packages in Serie A this season and kicks off at the Olimpico at 19.45 GMT.
Ederson is injured with Pedro Cavanda and Libor Kozak suspended, but Klose returns from injury to lead the attack with Hernanes, Stefano Mauri, Alvaro Gonzalez and Senad Lulic in support.
Abdoullay Konko has also shaken off a knock to start in defence.
Inter are looking to continue their strong run after beating Napoli to go into second place last week.
Dejan Stankovic, Joel Obi, Cristian Chivu and Gaby Mudingayi are out of action.
Cassano partners Milito with Fredy Guarin in the trequartista role, but Coach Andrea Stramaccioni changes to a 4-3-1-2 system.
Lazio: 22 Marchetti; 29 Konko, 20 Biava, 2 Ciani, 26 Radu; 24 Ledesma; 19 Lulic, 8 Hernanes, 15 Gonzalez, 6 Mauri; 11 Klose
Lazio bench: 1 Bizzarri, 84 Carrizo, 3 Dias, 21 Diakite, 5 Scaloni, 27 Cana, 87 Candreva, 23 Onazi, 32 Brocchi, 99 Floccari, 25 Rozzi
Inter: 1 Handanovic; 55 Nagatomo, 23 Ranocchia, 25 Samuel, 31 Pereira; 4 Zanetti, 21 Gargano, 19 Cambiasso; 14 Guarin; 22 Milito, 99 Cassano
Inter bench: 12 Castellazzi, 27 Belec, 6 Silvestre, 28 Pasa, 33 Mbaye, 40 Juan Jesus, 42 Jonathan, 17 Mariga, 41 Duncan, 24 Benassi, 7 Coutinho, 8 Palacio
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!