Napoli desperately try to get back on track in a stadium they haven’t conquered since 1946 as Siena make their Serie A debut under new Coach Beppe Iachini.
It’s crisis time for both clubs, as the Partenopei have lost three on the bounce in all competition and were eliminated from the Coppa Italia as holders.
This week Paolo Cannavaro and Gianluca Grava were given six-month bans, plus the club docked two points in the betting scandal.
Siena know all about that, as they started the season from -6 due to a different wave of the same investigation.
Serse Cosmi was sacked after three consecutive defeats and ex-Sampdoria boss Iachini drafted in on Monday.
This is his Serie A debut in the job, although he already took the helm in an unlucky Coppa Italia defeat to Lazio on penalties on Wednesday.
Simone Vergassola, Massimo Paci and Luis Neto are suspended for the home side, joining the injured Ze Eduardo, Andrea Campagnolo, Angelo and Alessio Sestu.
Napoli have Gokhan Inler on a one-match ban and Blerim Dzemaili on the treatment table, so Marco Donadel gets a rare midfield start.
Lorenzo Insigne partners Edinson Cavani, leaving Goran Pandev on the bench, while Hugo Campagnaro replaces Cannavaro in defence.
The Partenopei have an awful record in Siena, last winning here in 1946.
Siena: Pegolo; Dellafiore, Contini, Felipe; Belmonte, Bolzoni, D’Agostino, Valiani, Rubin; Rosina, Calaiò
Siena bench: Paolucci, Farelli, Marini, Rodriguez, Del Grosso, Mannini, Coppola, Verre, Reginaldo, Larrondo, Bogdani
Napoli: De Sanctis; Campagnaro, Gamberini, Britos; Maggio, Behrami, Donadel, Hamsik, Zuniga; Insigne, Cavani
Napoli bench: Rosati, Uvini, Aronica, Fernandez, Mesto, Dossena, El Kaddouri, Pandev, Vargas