It’s a blast from the past, some more recent than others, as Edinson Cavani, Andrea Dossena and Salvatore Aronica take on their former clubs.
There are familiar faces all round at the San Paolo, as Napoli hope to build on the momentum from their 4-1 hammering of Roma.
Cavani aims to score his 100th Serie A goal and could do so against the club where it all began for him, here partnered by Goran Pandev.
Both Lorenzo Insigne and his younger brother Roberto are on the Napoli bench.
On the other side, Dossena and Aronica only left Napoli in the last couple of weeks and already find themselves back in Naples wearing the Rosanero jersey, in the winger’s case his debut.
Josip Ilicic is suspended, with long-term injury absentees Abel Hernandez and Andrea Mantovani.
Fabrizio Miccoli is only fit for the bench, but Paulo Dybala is surprisingly benched in favour of Franco Brienza and Igor Budan.
Napoli: 1 De Sanctis; 14 Campagnaro, 5 Britos, 55 Gamberini; 11 Maggio, 85 Behrami, 88 Inler, 18 Zuniga; 17 Hamsik; 19 Pandev, 7 Cavani
Napoli bench: 22 Rosati, 3 Uvini, 4 Donadel, 13 El Kaddouri, 15 Colombo, 16 Mesto, 20 Dzemaili, 21 Fernandez, 24 L Insigne, 27 Armero, 42 R Insigne
Palermo: 1 Ujkani; 25 Von Bergen, 3 Aronica, 29 Garcia; 89 Morganella, 14 Anselmo, 5 Barreto, 20 Arevalo Rios, 8 Dossena; 21 Brienza, 19 Budan
Palermo bench: 99 Benussi, 6 Munoz, 9 Dybala, 10 Miccoli, 22 Brichetto, 23 Donati, 28 Kurtic, 50 Sanseverino
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!