Roma are forced to reshuffle their attack force in a difficult trip to Catania this afternoon, as Francesco Totti is injured in the warm-up.
These clubs have history of bad blood, which only intensified after the Sicilians threw away a 2-0 lead to be held 2-2 at the Olimpico in Week 1.
The Giallorossi go into this game without the injured Pablo Daniel Osvaldo and suspended Miralem Pjanic.
Therefore the trident attack was made up of Totti, Mattia Destro and Erik Lamela, while Daniele De Rossi is benched in favour of Panagiotis Tachtsidis.
However, Totti picked up a muscular problem in the warm-up and was replaced in the starting XI by Marquinho.
Catania are missing their talismanic midfielder Francesco Lodi on a three-match ban, while Marco Biagianti is also unavailable.
The traditional front line of Alejandro Gomez, Gonzalo Bergessio and Pablo Barrientos are in place, with Amidu Salifu stepping into the midfield.
Catania: Andujar; Bellusci, Legrottaglie, Spolli, Marchese; Izco, Almiron, Salifu; Gomez, Bergessio, Barrientos
Catania bench: Frison, Terraciano, Potenza, Augustyn, Alvarez, Capuano, Rolin, Paglialunga, Ricchiuti, Doukara, Castro, Keko
Roma: Goicoechea; Piris, Burdisso, Castan, Balzaretti; Florenzi, Tachtsidis, Bradley; Lamela, Destro, Marquinho
Roma bench: Lobont, Stekelenburg, Marquinhos, Dodò, Taddei, De Rossi, Perrotta, Totti