Lazio aim to get even closer to the top of the Serie A table when Miroslav Klose takes on Atalanta’s German Denis.
The Biancocelesti are unbeaten in 12 official games and sitting pretty in second place, having closed the gap from leaders Juventus to five points.
Ederson and Andre Dias are injured with Eddy Onazi on African Cup of Nations duty, but they have already won 1-0 in Bergamo in the opening round.
Atalanta are without Stefano Lucchini, Gianpaolo Bellini, Daniele Capelli and Guido Marilungo, while notching up one win in seven matches.
More importantly, the Orobici have lost their last four away games on the bounce without scoring for 229 minutes of football.
Denis hopes to change that trend with support from Maxi Moralez and Giacomo Bonaventura.
Lazio: Marchetti; Konko, Biava, Ciani, Radu; Ledesma; Candreva, Mauri, Hernanes, Lulic; Klose
Lazio bench: Bizzarri, Carrizo, Stankevicius, Scaloni, Zauri, Cavanda, Cana, Floccari, Rozzi, Kozak
Atalanta: Consigli; Raimondi, Stendardo, Canini, Brivio; Giorgi, Cigarini, Carmona, Bonaventura; Moralez; Denis
Atalanta bench: Frezzolini, Polito, Radovanovic, Cazzola, Parra, Milesi, Ferreira Pinto, Schelotto, Matheu, De Luca, Troisi
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.