Alessandro Matri starts in the stadium he left last week, as Juventus visit Cagliari, but Giorgio Chiellini moves to left-back and Alex Del Piero is benched.
The striker completed his transfer on deadline day, January 31, and made his debut in Wednesday's 2-1 defeat at Palermo.
Fate has put Matri up against his former teammates and fans in only his second game for the Bianconeri.
He partners Jorge Martinez, as Coach Gigi Del Neri has opted to leave captain Del Piero on the bench.
The injury lost includes Fabio Quagliarella, Simone Pepe, Vincenzo Iaquinta, Leandro Rinaudo, Armand Traoré and Paolo De Ceglie.
Luca Toni is back in the squad after tearing a ligament in his right knee on January 13, but is only fit for the bench, while Leonardo Bonucci's ban has expired.
With new signing Andrea Barzagli in central defence, Del Neri has moved Chiellini to his old left-back slot.
Cagliari miss Simone Laner, but give Robert Acquafresca the role in attack with support from Andrea Lazzari and Andrea Cossu.
Michael Agazzi is fit to start in goal despite suffering a head injury midweek.
Cagliari: Agazzi; Pisano, Canini, Astori, Agostini; Biondini, Conti, Nainggolan; Cossu, Lazzari; Acquafresca
Juventus: Buffon; Sorensen, Barzagli, Bonucci, Chiellini; Krasic, Aquilani, Melo, Marchisio; Matri, Martinez
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