Genoa make their debut under new Coach Davide Ballardini against Juventus, while Lazio face their bete noir Chievo.
Milan also visit Atalanta, Roma seek revenge at Bologna and Napoli have an intriguing clash at the Tardini.
Inter round off the weekend against Torino on Sunday evening.
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more