Antonio Cassano and Rodrigo Palacio lead the way as Inter welcome a Torino side that is unbeaten in five rounds.
San Siro hosts the final game of Serie A Week 22, which kicks off at 19.45 GMT. Click here for a match preview.
The Nerazzurri have to do without Diego Milito, Walter Samuel, Luca Castellazzi, Dejan Stankovic and Philippe Coutinho.
The 20-year-old Brazilian is believed to be on the verge of joining Liverpool for €12m.
Cassano returns from a thigh problem to partner Palacio in attack with support from Fredy Guarin.
Torino are unbeaten in five rounds, but have not beaten Inter home or away since 1994 and their last victory at San Siro was in February 1988.
Angelo Ogbonna is still out of action after a hernia operation, but Rolando Bianchi is on the bench despite returning from suspension.
Inter: Handanovic; Ranocchia, Chivu, Juan Jesus; Nagatomo, Zanetti, Gargano, Mudingayi; Guarin; Cassano, Palacio
Inter bench: Belec, Di Gennaro, Silvestre, Alvarez, Mariga, Rocchi, Cambiasso, Benassi, Pereira, Jonathan, Bessa, Livaja
Torino: Gillet; D’Ambrosio, Glik, Rodriguez, Masiello; Gazzi, Brighi; Cerci, Barreto, Meggiorini, Santana
Torino bench: Gomis, Basha, Di Cesare, Suciu, Bianchi, Caceres, Bakic, Vives, Darmian, Birsa
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!