Lazio aim to get back on track, but visit a revived Genoa side under new Coach Davide Ballardini and miss Hernanes.
The Biancocelesti dropped down to third place after last week’s surprise home defeat to Chievo, but beat Juventus to reach the Coppa Italia Final.
Hernanes suffered head trauma during that Coppa game and is out of action along with Antonio Candreva, Ederson and suspended duo Andre Dias and Giuseppe Biava.
Miroslav Klose returns for his first Serie A game in three weeks, partnering Sergio Floccari in what looks to be a 3-5-2 system.
Genoa are still in dire straits, but new boss Ballardini held Juve on his debut, albeit in controversial circumstances.
Luca Antonelli sits out a ban with the injured Antonio Floro Flores, Bosko Jankovic and Juan Manuel Vargas.
Marco Borriello is the lone centre-forward with support from Andrea Bertolacci, but new buys Daniele Portanova and Mattia Cassani make their debuts.
It’s a special game for Francelino Matuzalem, who left Lazio in January after a contract dispute.
Genoa: Frey; Granqvist, Portanova, Manfredini; Cassani, Kucka, Matuzalem, Rossi, Moretti; Bertolacci; Borriello
Genoa bench: Tzorvas, Ferronetti, Said, Nadarevic, Olivera, Tozser, Jorquera, Donnarumma, Immobile
Lazio: Marchetti; Ciani, Cana, Radu; Konko, Gonzalez, Ledesma, Mauri, Lulic; Floccari, Klose
Lazio bench: Bizzarri, Cavanda, Stankevicius, Brocchi, Candreva, Rozzi, Kozak