Lazio start with Sergio Floccari and Libor Kozak up front against Siena at Stadio Artemio Franchi this evening.
The capital club are looking for the three points that will take them back into the Champions League places, and do so with a slightly under-strength XI.
The Czech forward and veteran Italian start in a front two, with Hernanes and Alvaro Gonzalez playing in the centre of midfield.
Siena meanwhile are hoping for the win that will take them off of the bottom of the table, and start with January signing Innocent Emeghara as the lone front-man.
Siena: Pegolo; Teixeira, Terlizzi, Felipe; Belmonte, Vergassola, Della Rocca, Rubin; Rosina, Sestu; Emeghera
Lazio: Marchetti; Konko, Brava, Ciani, Radu; Candreva, Gonzalez, Hernanes, Lulic; Floccari, Kozak