Daniele De Rossi and Miralem Pjanic pulled out of training this morning complaining of muscle strains.
The midfield pair limped off earlier today in Roma's morning session, but it is as yet unclear how serious the injuries are.
Pjanic will have a fitness test tomorrow to see if he can play against Atalanta at the weekend, whilst De Rossi is suspended for the match.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!