Juventus look to Mirko Vucinic and Sebastian Giovinco as they hope to avoid becoming the latest big victims of Siena and Innocent Emeghara.
Over the last few weeks, Siena have beaten Inter and Lazio, while January signing Emeghara has netted four goals in three games.
The Swiss-Nigerian striker again starts with support from Alessandro Rosina and Francesco Valiani, while defender Jorge Texeira is a surprise pick.
Simone Vergassola has failed a fitness test and is not even on the bench.
Juve welcome back Claudio Marchisio and Federico Peluso from suspension, while Giorgio Chiellini is on the bench two months after tearing a calf muscle.
Martin Caceres joins Paolo De Ceglie, Nicklas Bendtner and Simone Pepe on the injury list, but Paul Pogba is given a rare start alongside Andrea Pirlo.
Juventus: Buffon; Barzagli, Bonucci, Peluso; Lichtsteiner, Pogba, Pirlo, Marchisio, Asamoah; Giovinco, Vucinic
Juventus bench: Storari, Rubinho, Chiellini, Anelka, Padoin, Vidal, Giaccherini, Quagliarella, Matri, Isla, Marrone
Siena: Pegolo; Jorge Texeira, Terlizzi, Felipe; Belmonte, Della Rocca, Rubin, Bolzoni; Rosina, Valiani; Emeghara
Siena bench: Farelli, Paci, Uvini, Mannini, Verre, Bogdani, Calello, Matheu, Agra, Grillo, Pozzi, Reginaldo