It’s a head-to-head for European qualification as Lazio welcome high-flying Fiorentina to the Stadio Olimpico.
The battle kicks off at 19.45 GMT, click here for a match preview .
Antonio Candreva sits out a ban for the home side, joining the injured Miroslav Klose, Abdoullay Konko and Cristian Brocchi in the stands.
The Biancocelesti are fresh from an impressive 2-0 Europa League victory away to VfB Stuttgart, putting them within reach of the quarter-finals.
Sergio Floccari leads the way with Ederson coming in after his goal in Stuttgart.
Fiorentina have been wildly inconsistent between their home and away form, but are eager to turn that tide in Rome.
Alberto Aquilani is suspended, while Michele Camporese, Giuseppe Rossi and Mounir El Hamdaoui are sidelined.
Giulio Migliacco steps into the midfield, while Juan Cuadrado returns from suspension for a trident attack.
Lazio: Marchetti; Pereirinha, Cana, Dias, Radu; Ledesma; Ederson, Gonzalez, Hernanes, Lulic; Floccari
Lazio bench: Bizzarri, Straicosha, Ciani, Biava, Onazi, Mauri, Saha, Kozak
Fiorentina: Viviano; Tomovic, Rodriguez, Savic; Pasqual, Migliaccio, Pizarro, Borja Valero; Cuadrado, Jovetic, Ljajic
Fiorentina bench: Neto, Lupatelli, Roncaglia, Compper, Romulo, Sissoko, Llama, Fernandez, Wolski, Larrondo, Toni
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.