Inter need to put White Hart Lane behind them, but have already had problems against Bologna so far this season and drop Antonio Cassano again.
The Nerazzurri were humiliated 3-0 by Tottenham in the Europa League on Thursday and are desperate to get back on track, especially with third place moving further out of their grasp.
Samir Handanovic sits out a ban, so Juan Pablo Carrizo gets his first Serie A start since May, as second choice goalkeeper Luca Castellazzi is out following shoulder surgery.
The injury list includes Diego Milito, Ricky Alvarez, Walter Samuel, Joel Obi, Matias Silvestre, Yuto Nagatomo and Gaby Mudingayi.
Rodrigo Palacio starts as the lone striker, as Cassano is left on the bench as he returns from being dropped for a blazing locker room row with Coach Andrea Stramaccioni.
Teenage midfielder Marco Benassi is a surprise starter with veteran Dejan Stankovic.
It is an extremely special game for two reasons. Inter were founded on March 9 1908 and captain Javier Zanetti plays his 600th Serie A match.
Bologna have already scared Inter once this season, as they fought back from 2-0 down to force extra time here in the Coppa Italia back in January. They were eventually beaten with the last kick of the game, an Andrea Ranocchia goal.
Panagiotis Kone is suspended, while Cesare Natali and Niccolò Cherubin are on the treatment table.
Alessandro Diamanti has been repeatedly linked with a move to Inter and he partners Alberto Gilardino in attack with support from Lazaros Christodoulopoulos and Manolo Gabbiadini.
Inter: Carrizo; Zanetti, Ranocchia, Juan Jesus, Pereira; Stankovic, Gargano; Schelotto, Guarin, Benassi; Palacio
Inter bench: Belec, Di Gennaro, Kovacic, Kuzmanovic, Rocchi, Cambiasso, Chivu, Pasa, Mbaye, Jonathan, Belloni, Cassano
Bologna: Curci; Garics, Sorensen, Antonsson, Morleo; Perez, Christodoulopoulos; Diamanti, Taider, Gabbiadini; Gilardino
Bologna bench: Agliardi, Stojanovic, Krhin, Moscardelli, Motta, Guarente, Abero, Riverola, Pazienza, Naldo, Carvalho, Pasquato