Lazio have to play behind closed doors when welcoming Stuttgart, but won the first leg of their Europa League tie 2-0 in Germany. It kicks off at 20.05 GMT.
The Biancocelesti are still unbeaten in the tournament this season, but have to play their next two UEFA matches behind closed doors due to repeated racist incidents among a small group of fans.
Stefano Mauri returns to the starting XI over a month after he sprained his ankle while treading on the ball during a goal celebration, supporting Libor Kozak.
Hernanes also starts, as he is suspended for Sunday’s game with Torino, while Eddy Onazi is given a chance after his sensational goal in Stuttgart.
The Germans welcome back Ibisevic from suspension to start in attack, as ex-Lazio man Federico Macheda is moved into a supporting trio.
Italian Cristian Molinaro also steps into the starting XI.
Lazio: Marchetti; Pereirinha, Biava, Ciani, Radu; Candreva, Onazi, Hernanes, Lulic; Mauri; Kozak
Lazio bench: Bizzarri, Ledesma, Gonzalez, Cataldi, Crecco, Floccari, Ederson
Stuttgart: Ulreich; Sakai, Tasci, Niedermeier, Molinaro; Gentnner, Holzhauser; Okazaki, Hajnal, Macheda; Ibisevic
Stuttgart bench: Ziegler, Felipe Lopes, Hoogland, Rudiger, Kvist, Traore, Harnik
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.