Wesley Sneijder and Lucio have not been called up for Saturday's match against Cagliari at San Siro.
Both players are carrying knocks and Inter don't want to run of the risk of further complications.
Leonardo is mindful of next week's Champions League clash with Bayern Munich on Wednesday.
It's his first match in Europe for Inter since he took charge in December.
Inter beat Bayern Munich in the Champions League Final last season.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.