Leonardo adopts a different approach with Goran Pandev, Houssine Kharja, Samuel Eto'o and Giampaolo Pazzini against Cagliari.
Inter kick off at 19.45 UK time at San Siro and are without the injured Wesley Sneijder, Diego Milito, Lucio, Walter Samuel or suspended Cristian Chivu.
In Sneijder's absence, Leo has chosen a 4-2-3-1 system with Pandev, Kharja and Eto'o supporting Pazzini as the lone centre-forward.
Yuto Nagatomo also starts at left-back, moving Javier Zanetti into midfield with Thiago Motta.
Cagliari have picked Nene and Robert Acquafresca with Andrea Cossu in the trequartista role.
Andrea Lazzari also has a deeper position in midfield with Daniele Conti.
Inter: 1 Julio Cesar; 13 Maicon, 15 Ranocchia, 2 Cordoba, 55 Nagatomo; 4 Zanetti, 8 Thiago Motta; 27 Pandev, 14 Kharja, 9 Eto'o; 7 Pazzini
Inter bench: 12 Castellazzi, 5 Stankovic, 17 Mariga, 19 Cambiasso, 20 Obi, 23 Materazzi, 29 Coutinho
Cagliari: 1 Agazzi; 14 Pisano, 13 Astori, 21 Canini, 31 Agostini; 8 Biondini, 5 Conti, 10 Lazzari; 7 Cossu; 18 Nenè, 9 Acquafresca
Cagliari bench: 25 Pelizzoli, 3 Ariaudo, 4 Nainggolan, 20 Laner, 23 Missiroli, 24 Perico, 30 Ragatzu
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.