Giuseppe Mascara does not start against his former club, as Napoli ring the changes and Catania give Gonzalo Bergessio his debut.
The Partenopei need a victory to retain second place after Inter overtook them with last night's win.
Ezequiel Lavezzi begins his three-match ban, while Hugo Campagnaro is also suspended, plus Luigi Vitale and Gianluca Grava sidelined.
Many expected Mascara to replace Lavezzi and start against the club he left in January, but he has been left on the bench in favour of Jose Sosa.
Walter Mazzarri rotates the squad following a midweek Europa League tie with Villarreal, so Hasan Yebda replaces Walter Gargano and Andrea Dossena is also rested.
Catania have a lengthy injury list, ruling out Mariano Izco, Giuseppe Bellusci, Christian Terlizzi, Ciro Capuano, Marco Biagianti and Francesco Fabio Sciacca.
The international transfer for Argentine hitman Bergessio finally came through this week and he is given his debut from the start, replacing Maxi Lopez.
Napoli: De Sanctis; Santacroce, Cannavaro, Aronica; Maggio, Yebda, Pazienza, Zuniga; Sosa, Hamsik; Cavani
Napoli bench: Iezzo, Ruiz, Cribari, Gargano, Dossena, Mascara, Lucarelli
Catania: Andujar; Potenza, Spolli, Silvestre, Marchese; Ledesma, Lodi; Schelotto, Martinho, Gomez; Bergessio
Catania bench: Kosicky, Augustyn, Alvarez, Carboni, Morimoto, Ricchiuti, Maxi Lopez
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