The Derby di Sicilia is set to be a fiery one, as Catania can push for Europe and potentially send rivals Palermo into Serie B.
It kicks off at the Stadio Massimino at 14.00 UK time (13.00 GMT), click here for a match preview .
While Catania are traditionally the less prestigious club, they are now the ones battling for European qualification while their neighbours are in the bottom three.
Sergio Almiron returns from an injury lay-off, though the Elefantini must do without Adrian Ricchiuti and Pablo Alvarez.
Palermo are missing Fabrizio Miccoli, who represents a huge loss, but Josip Ilicic has shaken off a knock to start this crucial match with Mauro Boselli.
The Rosanero have lost their last five consecutive trips to the Massimino.
Catania: 21 Andujar; 14 Bellusci, 6 Legrottaglie, 3 Spolli, 12 Marchese; 13 Izco, 10 Lodi, 4 Almiron; 28 Barrientos, 9 Bergessio, 17 Gomez
Catania bench: 1 Frison, 2 Potenza, 5 Rolin, 19 Castro, 26 Keko, 27 Biagianti, 30 Salifu, 32 Cani, 33 Capuano, 34 Messina, 35 Doukara
Palermo: 54 Sorrentino; 6 Munoz, 25 Von Bergen, 3 Aronica; 89 Morganella, 5 Barreto, 23 Donati, 28 Kurtic, 8 Dossena; 27 Ilicic, 17 Boselli
Palermo bench: 99 Benussi, 7 Viola, 9 Dybala, 11 Hernandez, 14 Anselmo, 16 Fabbrini, 18 Faurlin, 20 Arevalo Rios, 22 Nelson, 29 Garcia, 30 Brichetto, 33 Formica
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