Walter Samuel is the latest addition to the Inter injury list, as he will miss out on the trip to Palermo.
The defender had recently returned from a lay-off of several months, but suffered another tendon problem during training on Friday.
Although the squad list for Sunday’s game has not been released yet, Samuel is widely expected to be left at home.
The Nerazzurri are already without Rodrigo Palacio, Antonio Cassano, Fredy Guarin, Diego Milito, Esteban Cambiasso, Yuto Nagatomo, Walter Gargano, Joel Obi and Gaby Mudingayi.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!