Senad Lulic and Lorik Cana have not recovered in time for Lazio’s trip to Parma on Sunday afternoon.
The Biancocelesti are aiming to end a run of five consecutive away defeats and visit the Stadio Tardini.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview .
Lulic and Cana are still out of action along with Cristian Brocchi, but Abdoullay Konko is back in the squad after two months out.
Hernanes is carrying a knock, while Alvaro Gonzalez is suspended.
Lazio squad for Parma: Marchetti, Bizzarri, Scarfagna; Biava, Pereirinha, Stankevicius, Konko, Dias, Ciani, Radu; Onazi, Ledesma, Crecco, Hernanes, Ederson, Candreva, Mauri; Rozzi, Kozak, Klose, Saha, Floccari