Napoli host troubled Inter in a real Serie A classic, while Juventus could celebrate the Scudetto against Palermo and Milan face a Torino test.
Udinese welcome Sampdoria in the lunchtime kick-off, as they hope Lazio have another slip-up against Bologna.
In the relegation dogfight, Siena are in Catania and Genoa go head-to-head with Pescara, while Parma-Atalanta is a nervous affair.
Click here for all the individual match previews , plus reports from Saturday’s games Fiorentina-Roma and Chievo-Cagliari.
Check out OLBG.com 's list of ££ Free Bets from UK bookmakers before placing your bets!