Milan host Roma in what should promise to be a goal-packed encounter, while there are three lunchtime kick-offs including Fiorentina-Palermo and Genoa-Inter.
There is a triple appointment at 11.30am UK time (10.30 GMT), as Fiorentina-Palermo crosses the race for Europe with the relegation battle.
Genoa-Inter sees two teams who had hoped for so much more this season and Chievo-Torino has the Granata hoping not to be dragged down for the final round.
Delio Rossi faces his former club in Lazio-Sampdoria this afternoon along with Napoli-Siena and Udinese-Atalanta, then the Emilia-Romagna Derby is at 17.00 UK time.
This evening be ready for Milan-Roma at San Siro, a head-to-head for places in Europe.